In one of the best matches of the tournament so far, sixth-seed and crowd favourite Venus Williams lost 4-6, 6-4, 7-6 (3) to 10th-seeded Karolina Pliskova of the Czech Republic in the fourth round of the US Open at Flushing Meadows, New York on Monday.

"I was prepared that I'm going to play Venus. It's going to be tough, because all the people are cheering for her," Xinhua news agency quoted Pliskova as saying.

India's Rohan Bopanna and his Canadian partner Gabriela Dabrowski went down fighting in the quarter-finals of the mixed doubles competition at the US Open tennis tournament in New York on Monday.

Bopanna and Gabriela enjoyed a strong start before going down 6-1, 2-6, [8-10] to Robert Farah of Columbia and Germany's Anna-Lena Groenefeld in 58 minutes. 

French tennis player Lucas Pouille defeated 14-time Grand Slam champion Rafael Nadal over five sets, 6-1, 2-6, 6-4, 3-6, 7-6 (6), to reach the US Open quarter-finals at Flushing Meadows, New York.

"It took everything. I could not dream better than that," Pouille, the 22-year-old, said of his victory on Sunday. The match lasted four hours and seven minutes and it was decided by a fifth set tie-breaker. In the final-set tiebreak, Pouille held a 6-3 lead, with three match points on his racket before Nadal battled back to level it at 6-all.

Sania Mirza and her Croatian partner Ivan Dodig lost in straight sets to Barbora Krejcikova and Marin Draganja in the second round of the mixed doubles category at the US Open on Sunday.

The top seeded Indo-Croatian combination could hardly trouble their Czech-Croatian opponents, going down 3-6, 4-6 in an hour and five minutes.

Australia's Nick Kyrgios, the No.14 seed, was forced to withdraw from his third-round match at the US Open with Ukraine's Illya Marchenko due to a hip injury. 21-year-old Kyrgios, one of the rising stars on the ATP Tour, decided to retire at the start of the fourth set on Saturday night. Marchenko was leading 4-6, 6-4, 6-1 when the Australian's right hip injury worsened.

"Not the way I wanted to end the last grand slam of the year. F--king sucks," Kyrgios said in a Twitter post after the match.

Kazakhstan's Yaroslava Shvedova advanced to the US Open tennis fourth round with a 6-2, 7-5 victory over China's Zhang Shuai to set up a date with World No.1 and top seed Serena Williams, who brushed aside Sweden's Johanna Larsson 6-2, 6-1 at Flushing Meadows, New York on Saturday.

Shvedova dominated the first set on Court 5, striking nine winners to Zhang's four, breaking the Chinese player's serve twice and not facing a single break point. In the second set, the Kazakh No.52 made life more difficult for herself by putting just 46 percent of her first serves in play, thereby allowing Zhang to win many more points on return and convert two of her five break-point opportunities.